Enzymes are remarkable biocatalyst, responsible for all chemical transformations in living organism. The Kaila Lab, lead by Prof. Ville R. I. Kaila, is focused on understanding molecular principles of enzyme catalysis, with a special emphasis on how biological systems capture and store chemical and light energy and transduce this into other energy forms that the cell can use for energy-requiring processes. These processes are of key importance for understanding the molecular basis of cell respiration and photosynthesis, as well as human disease. To obtain insight in the structure, function, and dynamics of these fascinating biomolecules, we develop new methodology of computational biochemistry that we integrate with protein design and biophysical experiments. We are affiliated with Department of Biochemistry and Biophysics at Stockholm University with a subgroup at the Department of Chemistry, Technical University of Munich (Technische Universität München).
Our research is supported by the European Research Council (ERC), the Knut and Alice Wallenberg (KAW) foundation, the Swedish Research Foundation (VR), and Cancerfonden. Follow us in Twitter.
Recent key selected papers:
Kaila et al. (2021) Nature Rev. Microbiol. (in press);
Röpke et al. (2020) JACS 142:21758-21766;
Bridges et al. (2020) Nature Comms 5261, 11, 1–11:
Schuller et al. (2020) Nature Comms 11, 494: 1-7;
Jussupow et al. (2019) Science Adv. 5, eaav1850;
Saura et al. (2019) JACS 41: 5710-5719.
Warnau et al. (2018) PNAS 115: E8413-E8420.;
Mader et al. (2018) Nature Comm 9, 1168:1-8.;
Supekar et al. (2018) Chem Science 9:6703-6710.;
Gamiz-Hernandez et al. (2017) JACS 139:16282-16288;
Suomivuori et al. (2017) PNAS 114:7043-7048;
Di Luca et al. (2017) PNAS 114:E6314-E6321;
Sharma et al. (2015) PNAS 112:11571-11576;
Kaila et al. (2014) PNAS 111:6988-6993;
Kaila et al. (2014) Nature Chem 6:258-259.